Date: Tue, 4 Apr 2000 16:46:41 -0700

To: Recipient List Suppressed:;

(many thanks to all who contributed to this ~ Janna, Elliot, Lea, Gigi, and of course, Dr. Miller!)

From: Frederick Miller, MD, PhD

Yes, our studies are ongoing but we are trying to complete them soon. Please email me your phone number so I can discuss your specific case further.

Dr. Miller

Subject:[MM] FDA STUDY seeks MGUS/MM Patients w/wo

SILICONE BREAST IMPLANTS

Greetings everybody! I would like to present you all with this piece of information that I found. The FDA is conducting a study on relations between MGUS/MM and silicon breast implants. It is something to consider if you do or don't have implants:

Janna

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FDA SEEKING REFERRAL OF PATIENTS WHO HAVE DEVELOPED MONOCLONAL GAMMOPATHY OR MYELOMA AFTER SILICONE IMPLANTS OR INJECTIONS.

The Laboratory of Molecular Immunology of the Food and Drug Administration invites referral of patients for a study of the possible relationship between silicone implants or injections and monoclonal gammopathy or myeioma. We are studying subjects who received any type of silicone implant and later were diagnosed as having monoclonal gammapathy or multiple myeloma. We are also recruiting, as controls, individuals with monoclonal gammopathy or myeloma without silicone implants, as well as those with implants who are well and have no evidence of disease. Enrollment consists of completion of a questionnaire and donation of a blood sample.