TALCOTT TD

Source: INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY; 4

(1). 1995. 113-126.

Abstract:

BIOSIS COPYRIGHT: BIOL ABS. Long-term implantable medical devices require materials that are resistant to degradation by the corrosive environment of the body (or its cells) and must not release materials which cause sensitization or stimulate an immune response. Although silicones contained significant amounts of migratable low-molecular-weight cyclics (oligomers) and were known by the manufacturers to contain other migratable materials, they were thought by device users to fit those requirements.

Today the true amount and nature of silicone migratables are still not openly publicized. More recent data suggest that, because of these migratables, silicone materials may not be as safe as initially thought. There were many early warnings that were, at best, missed or at worst, ignored This review points out erroneous assumptions and some of the recent related research which may explain the chemical basis of silicone-caused diseases. It is hoped that continued exposure to silicone-caused diseases can.

Secondary Source ID: BIOSIS/95/34220